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Image Search Results
Journal: Oncology Letters
Article Title: CPSF3 is a promising prognostic biomarker and predicts recurrence of non-small cell lung cancer
doi: 10.3892/ol.2019.10659
Figure Lengend Snippet: Correlation of CPSF3 mRNA expression, and its DNA methylation and DNA copy number variants in TCGA-LUAD and in Cancer Cell Line Encyclopedia-LUAD cell lines. Correlation analysis revealed that (A) CPSF3 mRNA expression was not significantly correlated with DNA methylation at CpG site cg12057242, while (B) it was negatively correlated with its DNA methylation at CpG site cg25739938 in TCGA-LUAD. (C) Correlation analysis indicated that CPSF3 mRNA expression had no association with its DNA methylation in 53 LUAD cell lines. (D) Correlation analysis indicated that CPSF3 mRNA expression was positively correlated with its DNA copy number variants in TCGA-LUAD. (E) CPSF3 was positively correlated with its DNA copy number variants in LUAD cell lines. TCGA, The Cancer Genome Atlas; LUAD, lung adenocarcinoma; CPSF3, cleavage polyadenylation specific factor 3.
Article Snippet:
Techniques: Expressing, DNA Methylation Assay
Journal: Scientific Reports
Article Title: TRIM29 promotes epithelial–mesenchymal transition, angiogenesis, and stromal remodeling in lung adenocarcinoma: integrated validation at histologic, transcriptomic, and protein levels
doi: 10.1038/s41598-026-45469-2
Figure Lengend Snippet: TRIM29 function in the EMT pathway and TRIM29–drug sensitivity in DepMap LUAD. TRIM29 knockdown versus control in NCI-H441 and NCI-H650 cells ( A ). Wound healing assay according to TRIM29 knockdown in NCI-H441 and NCI-H650 cells ( B ). Heatmap of compound–cell line responses in the PRISM dataset ( C ). Bar chart showing the mechanism-of-action frequency among the top 50 compounds ( D ). EMT, epithelial–mesenchymal transition; DepMap, Cancer Dependency Map; PRISM, Profiling Relative Inhibition Simultaneously in Mixtures; MOA, mechanism of action
Article Snippet:
Techniques: Knockdown, Control, Wound Healing Assay, Inhibition